Neurobiology of Disease Pharmacological and Genetic Reversal of Age-Dependent Cognitive Deficits Attributable to Decreased presenilin Function
نویسندگان
چکیده
Sean M. J. McBride,1,2* Catherine H. Choi,1,2,3* Brian P. Schoenfeld,1,2* Aaron J. Bell,1,2 David A. Liebelt,1,2 David Ferreiro,1,2 Richard J. Choi,1,2 Paul Hinchey,1,2 Maria Kollaros,1,2 Allison M. Terlizzi,1,2 Neal J. Ferrick,1,2 Eric Koenigsberg,1,2 Rebecca L. Rudominer,1,2 Ai Sumida,4 Stephanie Chiorean,4 Kathleen K. Siwicki,5 Hanh T. Nguyen,1,2 Mark E. Fortini,6 Thomas V. McDonald,1,2 and Thomas A. Jongens4 1Section of Molecular Cardiology and 2Departments of Medicine and Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, 3Department of Dermatology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, 4Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, 5Department of Biology, Swarthmore College, Swarthmore, Pennsylvania 19081, and 6Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107
منابع مشابه
Pharmacological and genetic reversal of age-dependent cognitive deficits attributable to decreased presenilin function.
Alzheimer's disease (AD) is the leading cause of cognitive loss and neurodegeneration in the developed world. Although its genetic and environmental causes are not generally known, familial forms of the disease (FAD) are attributable to mutations in a single copy of the Presenilin (PS) and amyloid precursor protein genes. The dominant inheritance pattern of FAD indicates that it may be attribut...
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